Can tramadol induce hypomania?

17.09.2012

There are case reports of tramadol induced mood changes. ( e.g.: Tramadol-induced mania, B Vince Watts;Grady, Tana A,The American Journal of Psychiatry; Nov 1997; 154, 11 ).Tramadol is a centrally acting analgesic.It is a mu agonist. It inhibits reuptake of norepinephrine, serotonin and enhances serotonin release. It is molecularly similar to Venlafaxine.

Importance to psychiatrists: 1.  Increased risk of seizures with SSRI, TCA. 2. Reduce seizure threshold, hence caution while prescribing to individuals with epilepsy.3. Increased risk of serotonin syndrome with mirtazapine, SSRI and MAOI and venlafaxine.  3. Tramadol use can lead to dependence with withdrawal symptoms. 4.Tramadol can induce mood changes (e.g.: euphoria). 4.Tramadol can cause respiratory depression , hence caution essential while prescribing other medications with similar effect ( benzodiazepines) to patients who are at risk of overdose.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s